Plasminogen *
نویسنده
چکیده
With the availability of a method of purifying plasminogen from human Fraction IIL8 the therapeutic use of this enzyme in thrombotic conditions became a distinct possibility. Before attempting the clinical use of purified plasminogen, however, it appeared advisable to investigate the reporte that the enzyme responsible for the fibrinolytic activity can be separated from the agent producing proteolysis since this would make available a more desirable preparation for animal and clinical use. In addition, an investigation of the activation of plasminogen by streptokinase was considered desirable in view of the observation of Christensen1 that when plasminogen is activated by streptokinase, the solution obtained contains only a small percentage of the lytic activity which appears if the activation is carried out in the presence of substrate. The convincing demonstration by Cliffton, et al." that purified plasminogen, after activation by streptokinase in the absence of protective substrate, will dissolve clots in animals would make even more impressive the potent fibrinolytic power of this enzyme if Christensen's report is correct.
منابع مشابه
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ورودعنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 26 شماره
صفحات -
تاریخ انتشار 1954